منابع مشابه
Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action.
Insulin resistance is a predictor of the development of noninsulin-dependent diabetes mellitus (NIDDM) in humans. It is unclear whether insulin resistance is a primary defect leading to NIDDM or the result of hyperinsulinemia and hyperglycemia. To determine if insulin resistance is the result of extrinsic factors such as hyperinsulinemia primary skeletal muscle cell cultures were established fr...
متن کاملClinical experience with U-500 regular insulin in obese, markedly insulin-resistant type 2 diabetic patients.
On a clinical basis, severe insulin resistance is defined as a situation in which a patient requires 200 units of insulin daily for 2 days (1). This definition was determined 50 years ago, when it was erroneously believed that the human pancreas secreted 200 units of insulin a day. Although it is now known that the normal pancreas secretes only 20–40 units of insulin a day, this clinical defini...
متن کاملZataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats
Objective(s):In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ...
متن کاملBerberis integerrima ameliorates insulin resistance in high- fructose-fed insulin-resistant rats
Objective(s): This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the a...
متن کاملInsulin-Resistant Cardiomyopathy
Increasing evidence points to insulin resistance as a primary etiologic factor in the development of nonischemic heart failure (HF). The myocardium normally responds to injury by altering substrate metabolism to increase energy efficiency. Insulin resistance prevents this adaptive response and can lead to further injury by contributing to lipotoxicity, sympathetic up-regulation, inflammation, o...
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ژورنال
عنوان ژورنال: BMJ
سال: 1935
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.3874.697